Atividade Antitumoral de Extratos obtidos do Epicarpo de Plinia cauliflora (Mart.) Kausel sobre Tumor Sólido de Ehrlich

Abstract

He studied antitumor activity of an acetone extract of the fruit of Plinia cauliflora in Ehrlich tumor model. Mice were used for this experiment, they were divided into: Group I - tumor free animals treated with 9% NaCl (normal control); Group II animals with tumor treated with NaCl 9% (negative control); Group III - 400 mg / kg / day of acetone extract of P. cauliflora; and Group IV - tumor-bearing animals treated with 5-fluorouracil (20 mg / kg / day). On the eighth day of the experiment, blood tests were performed (white blood cell counts and red blood cells) and biochemical (glucose, total cholesterol, triglycerides, HDL-cholesterol, aspartate aminotrasnferase, alanine aminotransferase, urea and creatinine) by specific enzymatic methods. Treatment with acetone extract of P. cauliflora showed a significant antitumor activity, which was observed a reduction of 54.5% of the tumor mass. Treatment with acetone extract promoted a significant improvement in the levels of urea, creatinine, total cholesterol and glucose compared to the negative control group. In conclusion, treatment with the extract showed its antitumor success and did not portray any changes in markers of kidney and liver function, commonly found in marketed drugs.