Achados clínicos e laboratoriais em pacientes com dengue associados à hepatopatia: uma revisão de literatura

Abstract

This article revisits the clinical and laboratory findings of dengue that indicate liver involvement, from 2000 - 2014. The involvement of the liver with dengue is correlated with disease severity, being more frequent in patients with the Dengue Hemorrhagic Fever ( DHF). According to studies it was observed that it is extremely important view clinical and laboratory findings in patients who have dengue virus, especially with DEN-2 and DEN-3 serotypes, which may eventually develop liver complications. Pain in the right upper quadrant, hepatomegaly and jaundice are the most frequent clinical changes evidenced in patients with severe dengue. These liver changes are consequences of the aggression of the virus; immunopathology and hepatotoxicity due to the drugs used in treatment. The biochemical markers which are more altered as has the presence of liver diseases include: AST, ALT, bilirubin, prothrombin time (PT) and creatine kinase (CK). These changes are accompanied specific laboratory diagnosis for dengue, such as ELISA for IgM and IgG antibodies for the virus and virus isolation. Dengue can present clinical and laboratory aspects consistent with hepatic impairment and thus develop into a more serious picture of the disease. However, there is still much to understand about the infection by Dengue virus and its strains, especially those related to liver diseases.