Avaliação da expressão das fucosiltransferase 3 e 6 em tecido vascular de tumores prostáticos humanos.

Abstract

Prostate cancer and benign prostatic hyperplasia are the major benign and malignant tumors, respectively, that affect men around the world. Studies have shown that there is an expression of genes, leading to a relevant post-translational position in the development and invasion of prostate tumors. The aim of this study was to correlate Fucosyltransferases 3 and 6 without vascular endothelium in prostatic adenocarcinoma biopsies and benign prostatic hyperplasia, in order to identify non-tumoral proteins and their power to stimulate metastasis. Methodology: Biopsies were submitted to the immunohistochemical technique for the visualization of fucosyltransferases proteins 3 and 6 in the tissues. The immunoexpression was evaluated as an optical microscope in order to verify the presence or not of the markings on the vascular endothelium. Conclusion: The variation of FUTs in the two types of tissues was verified, but for the development of new biomarkers, it is done with more studies.